I've always joked that if it can't be loaded will with 7828 SSC or AA 2495, I probably don't want to hunt with it. Both are single base with decent temp stability, and both tend to have higher than expected performance.
7828 SSC covers 7mm magnum 175s and .375 H&H magnum 270+s. It's a little slow for the .375 H&H, but the energy density/efficiency combo is so high it produces nice loads that exceed factory while being 15% or so under pressure. This is a case where 7828 SSC does not use the same load data as 7828.
AA 2495 covers the big straight wall guns in the battery. It's the top powder in .45-70/.45-90, and simulation suggests it'll be top in my new .50-110 as well. It works best with extremely high load ratios (often > 120%) dispensed with a drop tube. Going down that road the .45-90 will happily exceed 4000 ft-lbs and the .50-110 should easily exceed 5000 ft-lbs with hunting softs. Northfork solids at 425 and 535 grains respectively can be driven over 2000 ft/s, which is more than enough for anything on earth.
If I was going to add a 3rd powder, it'd be H4350 for 7mm-08 and a faster option for light bullets in .375 H&H.
