Sierra is better for paper. That's about all Sierras are good for. Hornady Bullets are for game animals. I shot a doe in the shoulder with a Sierra Game King bullet, it never entered the lungs. It took several more bullets to drop the deer. Other hunters I know have had similar failures with Sierra's!
This happened to my brother on a real nice 10 point buck he shot with a 243. Smallish central Texas deer. He gave the rest of the box to me for coyotes. I ran into a herd of hogs and shot 5 or 6 aiming for shoulders. I found one small hog where the bullet went through the rear edge of the shoulder. Rancher was not impressed.