I don't have a 25-06, but I do have a 257 Weatherby Magnum. I have used successfully 120 gr. Nosler Partitions in hand loads. IMR 4831 at max. And Federals Premium 257 factory 115 gr. Trophy Bonded Bear Claw (no longer offered,but I bought many boxes) I have used them on all African PG, many the size of elk-kudu,zebra etc.. Both bullets are outstanding to say the least. I would use them on elk anytime. Guess I need to get around to picking up a 25-06. Its a great round. I wanna try out the Swift Scrirraco II.