Nanofil here. I use 10-lb Nanofil on my medium rods, and 6-lb on my ultralight. Matching fluro leaders on both, with either the Red Philips knot or uni-uni. I do note that Nano absolutely requires ultra-smooth line guides. A rough guide will shred it right away.
For heavier test, I go to Power Pro or Spectra. The heavier Nanofils aren't as good. Power Pro also works well on my casting reels. Same knots.
