Nanofil here. I use 10-lb Nanofil on my medium rods, and 6-lb on my ultralight. Matching fluro leaders on both, with either the Red Philips knot or uni-uni. I do note that Nano absolutely requires ultra-smooth line guides. A rough guide will shred it right away.
For heavier test, I go to Power Pro or Spectra. The heavier Nanofils aren't as good. Power Pro also works well on my casting reels. Same knots.
Almost identical setups. I use 12 on my medium lights and mediums and 6 on my lights and ultra lights. I love the red Phillips knot but if I'm in a hurry I tie a modified surgeons knot. I use a floro leader most of the time but a mono leader has more stretch and I lose less fish on a mono leader on heavyish lures like jigging spoons with treble hooks. It's good stuff that nanofil.
Have you tried sufix 832 Rocky? Just curious about it.
