I don't see any reason to load them at 35 Rem levels. I've used that bullet on deer from the 35 Whelen at full velocity and still didn't get as much expansion as most other bullets judging by the tissue damage and exits. My experiments with them in test media (so I could catch one) showed pretty much the same thing. They are a lot like XTP handgun bullets in that you get a little expansion of the nose but never a big wide mushroom.