Michelin Defender LTX MS... Hands down. Wife's 2001 Highlander has 240K miles. She put 140K on it. Three sets of the Michelin tires. Zero issues. Fourth set on right now. Just bought her a 2015 Equinox AWD. First thing we did was put a new set of the Michelin LTX tires on it. Not cheap. But, they ride smooth, channel water well, and have good traction in mud, gravel, snow. Good tread life and give good fuel economy.