You'll be happier moving 300+ grain bullets at decent velocities than trying to warp-speed 250gr bullets for a "flatter trajectory." With heavier bullets the 460 has an almost pleasant muzzle blast, although recoil goes up. They're good guns and almost always quite accurate. If you're a handloader, you'll be able to take advantage of the gun's versatility. A good place to start would be 360gr Oregon Trail Tru-Shot cast bullets over AA1680 powder. I've used those bullets in my 45 Colt and they've been quite accurate; AA1680 powder is an excellent powder for longer pistol cases like the 460 S&W. I've used it in my .357 Maximum to good effect.
