I have posted this before, but I'll say it again here. Back in 1990, just before I headed out on my second Colorado elk hunt, I wrote to Jim Carmichael and asked him if I should take my 280 or my 30-06. He very graciously wrote back and said that either would be fine, but his personal favorite elk rig was his custom 280 shooting 140 grain Nosler Partitions. I have that letter around somewhere. If the 280 with a 140 grain bullet is good enough for Carmichael it should be good enough for the rest of us.
