It depends on Terrain and conditions. I have killed more game with 6mm Rem than any other. In open country and or fresh snow cover I will shoot farther. The 6mm or .243 will kill deer size game effectively at 350yds. However your margin of error maybe less than say a 30/06/ Only because it will leave a bigger hole going out. That is why I want to be able to see them in open country or be able to track them. I have shot deer with a .44 cal Kentucky Rifle numerous times. But only use it when I have plenty of snow
