I have a reduced load for my 375 using (IIRC and thats a big if but I can go look if your interested) 225gr flat nose pistol bullet and IMR 4227 about 36gr once again using memory. It's not real fast maybe 1700, you can hear it hit paper at 100 yards BUT its very accurate and good out to 125 yards. I seldom have a shot that far and it's the hammer of Thor on deer. Recoil is similar to a 243.