The 257 Bob is excellent and the 257 Wby is spectacular. In between those two is the 25-06 and it is one hell of a cartridge. IMO it is the lightest recoiling, hardest hitting cartridge out there. The 25-06 is capable of killing both small and very large animals at extreme distances. The 308 Win is very capable and versatile as well, but the 25-06 is much flatter shooting out to 400 yards having light recoil in a 7 lbs rifle. I would only caution the use of a 25-06 with 22-inch barrel as the muzzle blast is much greater than the 308 Win with 22-inch barrel. The 25-06 is well suited to 24 and 26 inch barrels giving reduced muzzle blast. As others have stated sometimes muzzle blast can cause a shooter to fear the trigger.