I think it was about 1989 when Randy Brooks joined John Nosler as one of the most influential designers of premium hunting bullets and introduced the Barnes X bullet. If memory serves me correctly he then took the great Thee Seven Five H&H to Africa and tested his 270 grain X bullets on Cape Buffalo. The rest of the story is still being successfully written in the worlds hunting fields.

If I were using a .375 H&H in America I would use the 250 grain TTSX, in Africa I would use the 270 or 300 grain version and expect good results, if I did my part and put the bullet in the right place.