I and friends have shot some big ones with 22 rim fires but one big one took on a rodeo shoot with multiple hits required. Anything that works on deer is usually fine but when I know there are really big ones around it is nice to have more bullet penetration if needed. We saw one that we mistook for one of the cows it was among. The tracks looked like a cows too. One like that pushing 400 lbs and with two inches of gristle shield and then an unknown amount of mud over that makes a Mono or other premium bullet reassuring.

We never got that one but it was enough justification to get the 375s out just in case they were needed but mostly for fun.

"When you disarm the people, you commence to offend them and show that you distrust them either through cowardice or lack of confidence, and both of these opinions generate hatred." Niccolo Machiavelli