Not in a pistol, but, I can tell you the 250 gr 45 cal XTP's and 44 cal 240 gr XTP blow the crap out of deer and pigs, I worked up a couple loads for buddies shooting them in their muzzleloaders, proving both bullets will stay together and penetrate better from the slower speeds of a revolver, I remember seeing a handful of exits on rib and shoulder shot deer hunting with those guys, field dressing showed the bullets did a hell of a job, hope this helps.
I second the(230gr or 240gr?) XTPs on whitetails from a muzzleloader. Didn’t go far and lots of blood.