Buddy of mine used to swear by 180 gr. XTP's fired out of his Python .357. Don't recall the load and none of us owned a chronograph back then. Dropped a lot of deer that way over the years and never lost one or had one go very far. But then; they were all shot at bow hunting range from the same spots he used during bow season. I've always heard good things about the .45 cal. XTP's also.