49.0 grn of RL 22, Remington brass, 210's, and 175 Hornady RN's run 2500fps out of my 22" #1. It'll fling 3 into an 1-1/2" (I gotta try bedding that rifle) like most everything else.
Would love to run up on another box or two of RN's. Only thing I ever shot with them was a feral sow that weight around 125lbs. She was only about 15 yards away. Looked like you had shot a coffee cup all the way through her.
If I run out of RN's (which will be a while, no more than I get to hunt and shoot anymore), I'll prolly just run the regular Interlock.