I shot 2 deer last year with Hornady factory loads out of a 1895 Guide Gun with an 18 inch barrel at 40-60 yards. I was very impressed with the performance and lack of meet damage. The buck was quartering to and entrance through the shoulder and still lost very little meat. The doe went farther than ideal but my hit was farther back than I planned and I hit no bone. Good expansion but no blood trail. I don’t blame the bullet though as it clearly left 2 good holes. I wouldn’t hesitate to use this bullet again on deer at this velocity.