I have not used the TSX on game yet, but have loaded it for my .284 and .375 H&H proving very accurate. I have shot a caribou and recently a cow elk with the TTSX from my .338 WM. Very accurate also. The only problem I have had with the TTSX occurred after I shot the cow elk. I quickly reloaded after the shot and for some reason the cartridge went over the chamber and seemed to get hung up where the receiver and barrel connect. I had to fiddle with it to get it unstuck and when I did the tip was bent sideways. As I told my hunting partner, "I'm glad it wasn't a bear coming in fast when that happened." While a good bullet, that may have changed my mind to ever use them on dangerous game. While it may never happen again and was probably some problem with the rifle once a person loses faith in something it is hard to get it back. I have no problem using them otherwise. The rifle may not be used for it either.