100gr is my standard load, but 80gr punched 300gr XTPs through several deer for my sons. Of about a half dozen shot with 290gr T-EZ Barnes bullets, the only recovered one was from a frontal shot that lodged in the spine between the shoulders. That was an 80gr charge too. Really, I think it's mostly about what proves accurate in your gun and maybe just a bit about trajectory. Power is sufficient at any normal charge level. I've had excellent luck with Harvester Crush-Rib sabots, though I think the ones on the Barnes bullets are MMPs. CCI magnum primers are what I prefer, but others have worked well too. Your rifle will tell you what it likes; and shooting it is the only way to find out.
