Use 180 Nosler Partitions behind a max book load of H4350 and don't look back. This will work on everything from deer to moose and because it is a Partition, it will "open up and terminate". My Remington 700 SPS SS 30-06 groups them at .72 MOA off the bench and the crony says 2810 fps. Never had anything walk away from a 180.