Sir, Sorry to hear about glaucoma.
For rimfires, the two leaders in my mind are CZ452 (new), and Remington 581 (used). Personally, the Rem 581 is the only .22LR rimfire rifle that I own at the moment. The only downside for your situation is that the Rem 581 is Left Bolt, Right Port. I "beleive" that the CZ is Left Bolt, Left Port. I have not personally ever had any safety issues with the 581 Right Port to cause me concern. But YMMV...
For a bread and butter centerfire, it is hard to beat a LH Remington 700. Even in the left hand versions, you can still find enough parts and pieces to modify them to suit your particular needs. No flies on the Ruger Americans. I just prefer Remington.
Good luck with your search for south paw gear...
