I'm not perhaps the most accurate handgunner, but I have a .45 Colt/.45 ACP Ruger 5.5" Bisley and have no complaints as to its accuracy with either cartridge.
The weight of the gun makes the recoil of .45 ACP almost non-existent. It really is a cupcake.
Here is a link to one of my early range reports with some pics:
https://www.24hourcampfire.com/ubbt...olt-and-315-gr-cast-bullets#Post12767197