On a record of one elk, my .260 Rem 725 using 140 grain factory Corelokt did a bang/flop on an elk at around 150 yards.
People way over-think these things....
Which isn't to say I don't like my '06's and .338WM. With which I have taken, with various other calibers, around 100 caribou and moose, several sheep, bear, and one each lonesome goat and wolf.
Hint: It ain't what you hit them with, much, as where.