I've been using 44gr of IMR4350 with the 100gr TSX in my old Rem 722. Shoots about 3150 FPS in my rifle and have taken over a dozen critters with that load including Mule and Coues deer and a bunch of antelope. Never lost a critter, never recovered a bullet. Closest shot was 180 yards, longest about 350. Loaned it to a buddy and he killed his pronghorn over at 415.
BUT, based on Mule Deer's recommendation I'm going to give H4350 a try. I'm planning to give the Bob the season off this year in favor of the .270, .243, and .35 Whelen AI, so I have lots of time for loading the Bob.

Cheers,
Rex