I would not hesitate on a front on shot... And aim for a rear wheel hip socket...
Yep
A friend took (DLOP) what he could get - a front wheel socket for his first shot with a .30-06 at @30 yards. .No question of the bear's intent. Next 3 went in sideways, two of them lung hits, one gut.
At the time, and maybe still, the second oldest brown bear on record - 31 years. 9'2". Mouth full of rotten/broken teeth, Memorial day weekend - 4 inches of fat on the sucker. Just a sore toothed old curmudgeon. The bear.
I helped skin and pack it out 8 miles.