I've shot 2 deer last year using the 123gr Hornady SST and 29gr of 748. It chronographed at 2450 fps out of a 20" barrel. The range was less than 100 yds, but the results and tissue damage appeared comparable to my 7mm-08 I have used for years at that distance. Very consistent and accurate with or without my suppressor, but had to adjust gas block and rezero when I added the suppressor. Accuracy was the same maybe a little better. I used 748 powder simply because I had a lot I wanted to use up, worked well enough I didn't really see the need to try anything else. I was curious about CFE-223, but haven't tried it yet, really like it in the 5.56/.223 cartridge. One of the deer was a 190 lb field dressed buck, didn't go far after the shot. This is becoming my favorite deer gun and caliber.