I have a pair of 7.5" SRHs; one in .454 and one in .480. I've had the .480 for several years longer than the .454.
To my hand, the Hornady 325 grain .480 load kicks harder than the 300 grain Hornady .454 load. My handload consisting of the 400 grain Lee cast bullet over a full charge of 2400, also lets you know when you have pulled the trigger.

Those loads weren't exactly what I was looking for, so I bought a 290 grain plainbase SWC mold from Mountain Molds and load it to 900-1000 fps over a fast powder. Kinda like a larger version of .45 Colt. I like it. That load is a sweet shooter. And if the pesky pachyderms start raiding my garden, I still have the 400 grain mold.