I would say lighter bullets with highest velocity. The 125gr JHP factory 357 mag loads are good on just about everything up to deer and man at reasonable distances like 100yds. Should be very serious medicine for varmints as well.
^^^THIS^^^ The 125 gr bullets will break 2000 fps in rifle barrels. I'd have to dig out my notes but I seem to recall low 2100 fps in my 22" barrel H&R.
