If the animal is facing direct toward you, head down grazing, then a shot directly into the spine would be viable. You wouldn't want it too high, and risk doing no more than grazing the top of the spine, so you want to come down a bit from the "top" of the neck (as seen from this angle). I've taken that shot. I've also put them into the spine in the back of the neck as the animal faces or runs away with its head up. The actual target is narrow though, either from front or rear, and from front on you may be better off waiting for the animal to put its head up and either putting it into the base of the neck from underneath, or lower into the aorta above the heart.
