Do I have experience. No. But; for my 2c, the 460 WB delivers more velocity than desirable. Even if the bullets do not fail it is more penetration than you can use and with additional punishment. At best a big trade off in firepower and control for no gain or worse case trade off for more likely bullet failure. The Lott is about optimum for a 500 grain 45 caliber elephant round. Dont forget the Lott in a 602 or 550 holds 5 in the magazine for 6 shots! Compare that against 2 in a 460 magazine. If 458 is not enough, the next logical step up is to go 50 caliber. If you get 550 grain bullet at 2100fps good. Or a 600 grain bullet at 2400 fps you are maxed out. Beyond that, time to think about 577.
I believe Roy Weatherby wanted the most powerful rifle without any practical consideration or understanding of its use. The gun and the ammo was a joke. IMHO. He had an interesting idea with the 300. My respect went out the window with the 460.
