The .460 Weatherby was designed by mortal man for use by mortal man. Conjecture about potential for physical damage from using a .460 is not based on anything substantive.

I can say that a 550 grain bullet at just over 2500fps is a "thumper" that generates both visual effect and a cessation in further interests for the recipient.

When truth is ignored, it does not change an untruth from remaining a lie.