My wife and I have been using .243 Winchesters for deer and antelope for a few years now. We,ve been using 100 grain Hornady Interlocks and while that bullet kills just fine, in many cases it stays inside the chest cavity and doesn't exit. Because of this, it doesn't leave much of a blood trail. We've switched to 95 grain Nosler Partitions and hopefully now we'll get the complete pass through we're looking for.