Can't imagine needing a 150gr or heavier bullet for deer. Forever I have been taking large mature muley buck's with a 6.5 & 120gr Sierra's. Have shot muley's with every thing from a 243 up to a 338 mag. A 270 with a 110 gr bullet is an absolute deer killer out to 500yd. Have my own range & this works. With a 30-06 & the Sierra 125 gr , an absolute proven killer. 350 yds with the 30-06 & the Sierra 125 gr a chip shot with DRT results. If for what ever reason you feel you need a heavier bullet & that gives you confidence , go for it. The lighter bullets will give the quicker kills .