Can't really go wrong with any of the three. How about whatever shoots the best? The only brownie I shot was with a .375 cal 300 gr partition @ 2,400 fps. Went all the way thru on a broadside shot. We dug it out of the driftwood log he was standing in front of. Perfect mushroom.

On the monometals, I'd want speed over mass, so I'd lean towards the 165 gr on the TTSX @ 3,200 fps vs. 3,050 fps for the 180. Not sure the 180 is going to dig deeper. Shot the 200 gr partition in the '06 and '06 Imp. It would dig bow-to-stern on a good Sitka buck easily. Great bullet, but 75% weight retention on 200 grs is only 150 gr.

Uganik Lake, eh? Fly into the lake? Is there a public cabin on it?