Yes, it will certainly change your DOPE to switch between scope bases of differing inclination amounts.
Jordan, what you are saying is that the same load, rifle and scope sighted in at a 150' zero with a 0 MOA scope base would require a different number of clicks and mil adjustment to go to 300' with a 10 MOA scope base even if both 0 and 10 MOA bases where sighted in at zero at 150' ? Will the 10 MOA base usually require fewer clicks than the 0 MOA scope base?