Dunno if or where smallpox vaccine was made mandatory, but Smallpox killed over 300 million people over the years, and starting at one point a few decades ago it had been officially eradicated.
That's a Sh**t pot load more people than have been killed so far by Covid.
I have learned that isolated cases of smallpox pop up now and then, but the bottom line is that's a terrible disease that has been beaten.
If there is a release of the smallpox from one of the handful of labs that are the official guardians of the virus, there would have to be a government of some kind involved..