I shot a white tail doe at maybe 50 yards facing me with a 416 Taylor and a 300 gr Swift bullet. It traveled length wise and exited her back ham. Total meat loss was minimal.I worked up a reduced load in a Pre 64 M70 375 H&H but haven't tried it out yet as I bought a Ruger #1 and have a load using a 270 gr Speer at 2600 FPS. That and a 35 Whelen and a 405 Winchester will make it out this year. Whats REALLY fun is using my Heym 500 BPE rifle, It's a hammer gun with stalking safeties and a Jones under lever. I can easily hit a deer at 100 yards with it. The 365 gr cast bullet goes right through them and they are DRT.