What's the best get's asked about everything. Truth is there is no best of anything that I know of. Come's to powder in a 25-06 one guy likes one powder best and another guy something else, Which one is right. Now I have a system I've used for years for picking powder's. Seem's heavier for cal bullet's like slower powder better. I pick the bullet I want and look for the powder that gives the highest velocity with it. In my 25-06 the bullet is a 117gr Hornady Interlock. Off the top of my hear I think it's RL-22 I use with it. But I'm sure I could use a different powder and get results I could easily live with. But when no clue where to start, I simply look for where I get top velocity. Generally speaking, heavier bullet's in a cartridge usually use a slower powder to produce top velocities. If you don't care about velocity, just pick anything easy to find near home and go for it. Which ever you choose you'll probably find a suitable load.
