I've been using an excellent load of 69 grains RL-15 and the 260 grain Nosler Accubond for 10+ years from my 375 H&H. It's accurate, makes about 2650 fps, and has done a nice job on several black bears.

I'm very low on RL-15, but long on Varget...

Think a good load could be brewed up with 260/270 gr bullets and Varget?

I know that years ago during a Varget shortage, I built great 308 Win load with RL-15... The two were very similar in accuracy & velocity. Not sure that means anything re the 375 H&H though.

Thanks!