Loaded to their usual respective pressures the 375 moves ahead by quite a bit. If you load the 35 Rem up to pressures a modern 336 is capable of you will reach similar ballistics but are on your own for charge weights as no manual I know of supports this loading and internet sources like Paco have always struck me as sketchy. I really like the whole idea of the 375 and the 255 Barnes at 1900-2000fps is quite a load. The original top eject Big Bore is light, super handy and built for 50,000 PSI. What's not to love?