For the typical suburban, gun-glutt style gun collector /occasional deer hunter, you probably won't notice a difference between the two, loaded to their respective pressures.

Up north here, Yukon, north 61, and mself have seen real deal killing power from the little 375 Winchester on large moose, caribou and bear.

Talk about cheap: my childhood model 94 was sent to Jes reboring. Back then it was $175 to rebore. He recommended rl 10x for low pressure/top velocity and claimed the 375 didn't need to be in the big bore.

That gun was fed hundreds of reloads. Everything from resized 30-30 brass, starline 38-55 brass and 375 Winchester brass. With so much meat taken out of the barrel after rebore it was very light and handy. The quickness to recover from recoil for shot #2, my son always reached for it, when he headed into the mountsins to hike-harden Malamute puppies.

Top: 35 rem speer data
Bottom, 375 win. Hornady data. That's a substantial difference.

It it were me, I'd skip right over the 35 rem and go right to the 356 Winchester.

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Last edited by mainer_in_ak; 03/19/21.