What Fotis said (yes) + 1.
My Miroku/Winchester 1886 45-90 TD has taken a lot of game with factory 300 grain .45-70 ammo at 1800 + fps.
Most of my handloading has been for .45-90 loads for Africa and other special purposes.
Obviously, it is prudent to clean the chamber after shooting much 45-70 ammo.