I think the 222 case is more user friendly over the Fireball case...
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I would be inclined to agree with John. I love the deuce and am building another one...Ive never messed with the .20-222 wildcat mainly because there isn't much bullet selection in the .20 cal..it is strictly a varmint proposition.
With the .222 and a variety of bullets I can ( and have...) gone from ground squirrels up to deer and hogs comfortably.