I have killed them with 22 LR 22 WMR, 222 Rem, 223, and 22-250 but the only 17 I ever used was my Dad's 17 Remington SAKO. The first coyote I ever killed was when I was a boy of about 9 years of age with a 22 LR Pump rifle. (Winchester M62A which was my Dad's, and I still own it today) In fact I'd bet the first 10 I killed were all with the 22.
I've killed a lot with larger rifles and handguns too, but those above are the calibers I used that are commonly thought of as "Varmint calibers".

Since the subject is about rim rifles I can say my rim rifle experience was with 22 LRs and 22 WMRs from both rifles and handguns.

The 22LR with solid HV 40 grain bullets kill them fine. Not as dramatic as the center fires, but I can't ever remember shooting one with a 22 that got away even when I killed them with a revolver.

Last edited by szihn; 06/09/21.