The first two antelope I shot was with my Dad's 243. Then I got a 270 Win for Deer hunting. I used the 270 for all my antelopes after that. I would like to shoot another one with the 243 again. Normally anything you have for deer will work for an antelope. I do have a 7-30 Waters that might be fun antelope hunting with it does not have the range I am looking for. If I was to build a gun for antelope hunting I would look in the 6, 6.5 or 7 mm. I have been hunting with people using the 30.06 and it kills them too.