seen a knee doctor about 6 months ago for knee pain, he told me to take 1500mg of glucosamine sulfate, not plain glucosamine, start with one 1500mg once a day if knee still hurts then take twice a day, I only ever needed one so far, knees feel great. I get mine through wal mart I order on line. doc also told me don't let anyone near your knees with a needle, they will screw your knees up