I agree with tx35w. There's definitely something different about stepping up bore size. Results seem different.
Exit of a 225gr Accubond at about 70yds. Entrance was an inch higher and couple inches back. Not a CNS hit.
Straight down in a pile.
Made a lot of similar hits with 308s and 3006s and it always resulted in a death run. Not a huge deal. But there's in a lot of guys experiences there is something different when a 35+cal bullet hits.