i regularly shoot 22wmr out of a ruger single six, perfectly fine experience.
i did shoot 22wmr out of a heritage, not that great. the alloy barrel quickly heats up. the screws can shake loose. you feel more through the alloy frame.

think of running two cars around on a racetrack. the rss is a ford mustang shelby gt. the hrr is a ford focus st. the former was built to do the job. the latter is a cheap wannabe.