That's easy. I have no interest in Africa, Big Bears, or Varmints, apart from gophers...

22lr scoped, w/ backup open sights - 77/22 All Weather
Lightweight 308 - Kimber MT
Midweight 308 w/ backup open sights - M70 SS
12 Gauge Pump Shotgun - Remington 870
Glock 19 or SS 4" Ruger Security Six - I have both but push to shove would probably go Glock.

“Perfection is Achieved Not When There Is Nothing More to Add, But When There Is Nothing Left to Take Away” Antoine de Saint-Exupery